Table 2.
Variables associated with the evolution of the disease activity score from 28-joint count with three parameters (DAS28-3), the Health Assessment Questionnaire (HAQ) score, and the Larsen score in the EMECAR cohort
| DAS28-3 | HAQ score | Larsen score | ||||
| Bivariate | Multivariate | Bivariate | Multivariate | Bivariate | Multivariate | |
| Female gender | 0.57 (0.36 to 0.78)*** | - | 0.42 (0.29 to 0.55)*** | - | 6.49 (1.53 to 11.45)* | - |
| Age at baseline | 0.001 (-0.006 to 0.007) | - | 0.004 (0 to 0.008)* | 0.002 (0 to 0.004)* | -0.19 (-0.34 to -0.03)* | 0.009 (-0.025 to 0.043) |
| Age at disease onset | 0.006 (-0.002 to 0.007) | 0.002 (-0.002 to 0.007) | 0.20 (0.016 to 0.024)*** | - | 0.57(0.42 to 0.73) | - |
| Disease duration | 0.004 (-0.007 to 0.015) | - | 0.017 (0.009 to 0.024)*** | - | 0.94 (0.55 to 1.34)*** | - |
| Extra-articular rheumatoid arthritis | 0.32 (0.15 to 0.4)*** | 0.16 (0.04 to 0.28)* | 0.22 (0.13 to 0.31)*** | 0.03 (-0.02 to 0.09) | 0.06 (6.35 to 11.76)*** | - |
| Rheumatoid factor | 0.19 (-0.03 to 0.41) | 0.02 (-0.12 to 0.16) | 0.14 (0.01 to 0.28)* | 0.03 (-0.04 to 0.1) | 7.96 (3.19 to 12.72)** | 0.71 (-0.37 to 1.80) |
| Hemoglobin (g/dl) | -0.29 (-0.34 to -0.25)*** | -0.19(-0.23 to -0.15)*** | -0.1 (-0.12 to -0.07)*** | -0.03 (-0.05 to -0.01)** | -0.95 (-1.61 to -0.28)** | -0.04 (-0.32 to 0.25) |
| Hypertension | 0.05 (-0.11 to 0.21) | - | 0.19 (0.11 to 0.27)*** | 0.05 (-0.01 to 0.11) | 2.74 (0.4 to 5.08)* | -0.34 (-1.3 to 0.61) |
| Diabetes mellitus | -0.01 (-0.27 to 0.24) | - | 0.07 (-0.08 to 0.22) | - | -1.87 (-6.54 to 2.8) | - |
| Hyperlipidemia | -0.14 (-0.31 to 0.03) | 0.08 (-0.05 to 0.21) | -0.5 (-0.14 to 0.04) | - | -1.44 (-4.71 to 1.84) | - |
| Peptic ulcer | 0.17 (-0.13 to 0.47) | - | 0.15 (0.02 to 0.28)* | 0.05 (-0.03 to 0.13) | 1.30 (-3.06 to 5.66) | - |
| Myocardial ischemia | -0.05 (-0.33 to 0.23) | - | 0.17 (-0.08 to to0.42) | 0.06 (-0.09 to 0.21) | -0.49 (-6.56 to 5.58) | - |
| Heart failure | 0.31 (0.04 to 0.59)* | 0.06 (-0.21 to 0.33) | 0.36 (0.21 to 0.50)*** | - | -0.74 (-7.21 to 5.72) | - |
| Stroke | 0.15 (-0.2 to 0.49) | - | 0.02 (-0.27 to 0.3) | - | -8.94 (-13.79 to -4.09)*** | - |
| Chronic obstructive pulmonary disease | -0.1 (-0.38 to 0.17) | - | 0.01 (-0.13 to 0.14) | - | 2.2 (-3.23 to 7.64) | - |
| Neoplasm | -0.29 (-0.61 to 0.03) | - | 0.01 (-0.12 to 0.14) | - | -1.96 (-9.92 to 6.01) | - |
| Liver disease | 0.11 (-0.1 to 0.33) | - | -0.2 (-0.11 to 0.08) | - | -3.63 (-9.01 to 1.76) | -2.57 (-5.07 to -0.07)* |
| Depression | 0.27 (0.09 to 0.46)** | 0.12 (-0.03 to 0.26) | 0.15 (0.05 to 0.25)** | 0.02 (-0.05 to 0.09) | -0.79 (-3.61 to 2.03) | - |
| Body mass index | 0 (-0.02 to 0.02) | - | 0.01 (0 to 0.02) | 0 (-0.01 to 0) | -0.78 (-1.16 to -0.4)*** | -0.16 (-0.65 to 0.33) |
| DAS28-3 (each visit) | - | - | 0.17 (0.15 to 0.19)*** | 0.15 (0.13 to 0.17)*** | 0.37 (-0.23 to 0.98) | - |
| DAS28-3 (baseline) | 0.62 (0.57 to 0.67)*** | 0.53 (0.48 to 0.59)*** | 0.24 (0.2 to 0.28)*** | -0.1 (-0.13 to -0.07)*** | 6.79 (5.42 to 8.15)*** | 0.68 (0.26 to 1.11)** |
| HAQ score (each visit) | - | - | - | - | 4.92 (3.61 to 6.24)*** | - |
| HAQ score (baseline) | - | - | 0.85 (0.82 to 0.88)*** | 0.82 (0.78 to 0.86)*** | - | - |
| Larsen score (baseline) | - | - | - | - | 0.97 (0.95 to 0.99)*** | 0.96 (0.94 to 0.98)*** |
| Year | ||||||
| ∘ 2000 | Reference | Reference | Reference | Reference | Reference | Reference |
| ∘ 2001 | -0.3 (-0.4 to -0.2)*** | -0.23 (-0.33 to -0.13)*** | 0.01 (-0.03 to 0.05) | 0.04 (-0.02 to 0.09) | NA | NA |
| ∘ 2002 | -0.32 (-0.43 to -0.21)*** | -0.27 (-0.38 to -0.15)*** | 0.06 (0.01 to 0.11)* | 0.07 (0.01 to 0.13)* | 2.09 (1.32 to 2.86)***° | 2.07 (1.1 to 3.04)*** |
| ∘ 2003 | -0.47 (-0.58 to -0.36)*** | -0.4 (-0.53 to -0.27)*** | 0.05 (0 to 0.11) | 0.11 (0.04 to 0.18)** | NA | NA |
| ∘ 2004 | -0.5 (-0.63 to -0.37)*** | -0.43 (-0.58 to -0.28)*** | 0.09 (0.03 to 0.15)** | 0.15 (0.07 to 0.22) | 4.18 (2.68 to 5.68)*** | 4.4 (2.68 to 6.12)*** |
Data presented as β coefficient (95% confidence interval). NA, not available. ***P < 0.001, **P < 0.01, *P < 0.05.