Table 2.
Major studies in which chorea, including HD, patients were treated with TBZ showing treatment outcome
| Authors and year of publication | Number of patients | Outcome measures | Outcome |
|---|---|---|---|
| Huntington study group 2006 | 84 HD patients | Reduction in chorea score of the UHDRS | 5 point reduction in HD compared to 1.5 in placebo patients (p < 0.0001) |
| Vuong et al 2004 | 76 pediatric patients | Chorea improvement by CGIC | 89% of the patients improved |
| Paleacu et al 2004 | 118 patients with hyperkinetic movement disorders, 28 HD | CGIC | 61% of patients improved (chorea improved in 19/28 patients) |
| Ondo et al 2002 | 19 HD patients | AIMS | 79% of patients improved (15/19) |
| Jancovic and Beach 1997 | 400 hyperkinetic patients, 29 HD | Modified CGIC (from 1–5) | Overall improved by 82.8% 97% of chorea patients improved (28/29) |
| Jancovic 1982 | 20 hyperkinetic patients | Functional | 62% of patients improved |
| Asher and Aminoff 1979 | 26 patients with chorea, TD, tics | Clinical | 54% of chorea patients improved |
| Kingstone 1979 | 40 hyperkinetic patients | Clinical | 75% marked to moderate improvement |
Abbreviation: UHDRS, unified Huntington disease rating scale; CGIC, clinical global impression of change; AIMS, abnormal involuntary movement scale