Figure 1.

Potential cascade of events mediating and moderating SSRI effects. Used with permission from Adis International (Lotrich and Pollock 2005).

Abbreviations: BDNF. Brain-derived neuprtrophic factor; COMT, catecholamine-Omethyl-transferase; CRH, corticotrophin-releasing hormone; CRH2, CFH receptor 2; cAMP, cyclic adenosine monophosphate; CRED, cAMP response element binding protein; DARPP-32, dopamine and cAMP regulated phosphoprotein; DAT, dopamine transporter; MAOA, monoamine oxidase A; NOS, nitric oxide synthase; NET, norepinephrine transporter; 5-HT, serotonin; SERT, serotonin transport; SSRI, selective serotonin reuptake inhibitor; TPH, tryptophan hydroxylase.