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. Author manuscript; available in PMC: 2009 Dec 31.
Published in final edited form as: J Am Chem Soc. 2008 Dec 31;130(52):17858–17866. doi: 10.1021/ja8059864

Figure 2.

Figure 2

The mechanism of the cyclization of HpPNP with the catalyst (1) concluded from kinetic data. Kinetic data demonstrate that a complex between the substrate and 1 forms; because the binding mode is uncertain, the substrate and catalyst are depicted separately. The Zn-coordinated hydroxide deprotonates the nucleophilic alcohol prior to the nucleophilic step, and the dinuclear Zn center provides transition state stabilization.