Table 1.
Subject Characteristics for In Situ Hybridizations
| Age (Years) | Sex | PMI (min) | pH | Cause of Death | |||
|---|---|---|---|---|---|---|---|
| Control Subjects | |||||||
| 79* | F | 181 | 6.3 | CPF | |||
| 96* | F | 195 | 6.7 | CPF | |||
| 90* | F | 250 | 6.0 | CPF | |||
| 69 | M | 255 | 6.3 | Unknown | |||
| 64 | F | 1145 | 6.1 | Pulmonary edema | |||
| 93 | M | 1140 | 6.4 | Congestive heart failure | |||
| 102 | F | 423 | 6.5 | Acute Myocardial Infarction | |||
| 73 | F | 203 | 6.3 | Acute Myocardial Infarction | |||
| 79 | F | 460 | 6.5 | Acute Myocardial Infarction | |||
| 84 | F | 1110 | 6.2 | Unknown | |||
| 101 | M | 280 | 6.8 | Coronary artery disease | |||
| mean ± SD: 85 ± 13 | 3M / 8F | 513 ± 407 | 6.4 ± 0.2 | ||||
| Subjects with Schizophrenia | Subtype | Medications | Weeks med free | ||||
| 84 | F | 935 | 6.2 | Unknown | par | thi/chl | 115 |
| 61* | M | 212 | 6.5 | CPF | undif | per/hal/ser | 1 |
| 69* | M | 270 | 6.4 | Cardiac infarction, renal failure | par | hal/flu/tri/chl | 6 |
| 63* | M | 372 | 5.9 | CPF | undif | hal | 0 |
| 69* | F | 820 | 6.2 | CPF | undiff | thi/tri | 4 |
| 87* | M | 670 | 6.5 | CPF | undif | thi/tri | 11 |
| 68* | M | 335 | 6.8 | CPF | par | pro | 2 |
| 85 | M | 320 | 6.3 | CPF | undiff | flu/chl | 0 |
| 73 | M | 475 | 6.5 | Cardiorespiratory failure | disorg | hal | 0 |
| 66 | M | 725 | 6.5 | Acute cardiac failure | undif | unknown | unknown |
| 76 | F | 1270 | 6.1 | Cardiogenic shock | par | flu/tri/chl | 0 |
| 97 | M | 555 | 6.5 | CPF | undif | hal | 0 |
| 66 | M | 504 | 6.7 | CPF | sa | hal | 0 |
| 82 | F | 1126 | 6.6 | CPF | res | ris | 124 |
| 79 | F | 595 | 6.8 | Cardiac Arrest | undif | thx | 364 |
| 68 | M | 1036 | 6.6 | CPF | cat | flu | 0 |
| 86 | F | 415 | 5.8 | Respiratory insufficiency, renal failure | cat | thx/chl | 36 |
| 65* | F | 350 | 5.9 | CPF | undif | unknown | unknown |
| 79* | F | 1225 | 7.1 | CPF, cancer of pancreas | undif | thi/thx | 9 |
| 84* | M | 372 | 6.5 | CPF | undif | hal/per/thi/chl | 106 |
| mean ± SD: 75 ± 10 | 12M / 8F | 629 ± 333 | 6.5 ± 0.3 |
Abbreviations: post-mortem interval (PMI), standard deviation (SD), female (F), male (M), cardiopulmonary failure (CPF), paranoid (par), undifferentiated (undif), disorganized (disorg), schizoaffective (sa), residual (res), catatonic (cat), medication (med), Thioridazine (thi), Chlorpromazine (chl), Perphenazine (per), Haloperidol (hal), Trifluoperazine (tri), Prochlorperazine (pro), Fluphenazine (flu), Thiothixene (thx), Risperidone (ris).
Asterisks indicate subject is present in both in situ hybridization and Western blot analysis cohorts.