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Average percentage of responding on the nicotine-appropriate lever (top panels) and response rates (bottom panels) from combination tests with adenosine antagonists in nicotine-trained rats. Nicotine dose-response curves after pretreatment with vehicle or CPT (A) or MSX-3 (B) or caffeine (C). Data are means (±S.E.M.) from 10–11 rats (A), 8–9 rats (B) or 12 rats (C).
