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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2008 Aug 8;203(2):355–367. doi: 10.1007/s00213-008-1270-0

Figure 6.

Figure 6

Average percentage of responding on the drug-appropriate lever (top panels) and response rates (bottom panels) from pretreatment tests with adenosine antagonists in methamphetamine- or cocaine-trained rats chronically exposed to caffeine in their drinking water. Methamphetamine (A) and cocaine (B) dose-response curves after intraperitoneal pretreatment with 1.0 ml/kg of vehicle or caffeine at doses 10 mg/kg (methamphetamine group) or 3 mg/kg (cocaine group), or 3 mg/kg CPT or 3 mg/kg MSX-3. Data are means (± S.E.M.) from 9 rats (methamphetamine-trained rats) and 5–6 rats (cocaine-trained rats). *p < 0.05, **p < 0.01, post hoc comparison with the vehicle pretreatment after significant ANOVA for repeated measures main effect, Dunnett’s test.