Table 2.
In vivo hemodynamics
| NTG | β-TG | cMyBP-CWT:(t/t)/β | cMyBP-CAllP+:(t/t)/β | |||||
|---|---|---|---|---|---|---|---|---|
| Basal | Dobut. | Basal | Dobut. | Basal | Dobut. | Basal | Dobut. | |
| Heart rate (bpm) | 382±10 | 597±17 | 295±21* | 399±35* | 322±11* | 425±15* | 346±16 | 561±20# |
| LVP (mm Hg/s) | 108±5 | 121±7 | 77±4* | 86±2* | 79±5* | 94±3* | 103±4# | 113±4# |
| dP/dtmax (mm Hg/s) | 10253±561 | 24575±627 | 5631±363* | 13789±689* | 6555±396* | 14322±529* | 12680±455*# | 18395±479*# |
| dP/dtmin (mm Hg/s) | -9767±-617 | -18687±-867 | -5410±-339* | -8630±-806* | -5916±-1006* | -9164±-404* | -8860±-951# | -12291±-1084*# |
Cardiac catheterization was used to evaluate LV function.1 Heart rate, peak LV pressure (LVP) maximum, LV dP/dtmax (an index of myocardial contractility) and LV dP/dtmin (an index of myocardial relaxation), were determined at baseline (basal) and during infusion of dobutamine (Dobut; 32 ng/g/min). All data are presented as mean±SE.
*
P<0.001 versus NTG
#
P<0.05 versus cMyBP-CWT:(t/t)/β (n=6).