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. 2008 Dec 26;85(4):595–605. doi: 10.1189/jlb.1008631

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Fig. 3. — The trafficking deficit exhibited by SR-A^+/−TLR4^+/− BMDC is specific to SR-A-mediated phagocytosis and does not impair SR-A-mediated endocytic uptake. (A) WT, TLR4^−/−, SR-A^−/−, and SR-A^−/−TLR4^−/− BMDC were incubated with Alexa488-labeled AcLDL for 20 min at 37°C and analyzed quantitatively by FACS for endocytic uptake of AcLDL. SR-A^−/− and SR-A^−/−TLR4^−/− BMDC exhibited significant (*, P<0.01) deficits in AcLDL uptake compared with WT cells, and TLR4^−/− BMDC were similar to WT BMDC. (B) WT, TLR4^+/−, SR-A^+/−, and SR-A^+/−TLR4^+/− BMDC were treated as in A and analyzed for AcLDL uptake by FACS. Single heterozygous genotypes and the double heterozygous BMDC exhibited WT levels of AcLDL uptake.