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. Author manuscript; available in PMC: 2009 Mar 16.
Published in final edited form as: Neuroscience. 2005;130(2):383–388. doi: 10.1016/j.neuroscience.2004.09.012

Fig. 1. DNAzyme and its mRNA substrate of mPer1.

Fig. 1

(A) A 10–23 DNAzyme structure with substrate cleavage occurring at the position indicated by the arrow. (B) Sequence and structure of mPer1 DNAzyme annealed to the mPer1 substrate. The arrow indicates the cleavage site. (C) Sequence of the control ODN. To inactivate enzymatic activity of the DNAzyme, two nts (black) in the intervening 15-nt catalytic domain were altered.