Table 3.
Genotype distribution in relation to histological type in lung cancer
| Genotype | Adenocarcinoma | Squamous Cell Carcinoma | ||||||||||||||
| patients (n = 67) |
controls (n = 121) |
crude | adjusted | patients (n = 31) |
controls (n = 121) |
crude | adjusted | |||||||||
| n | % | n | % | OR (95%CI)a |
P-value | OR (95%CI)a |
P-value | n | % | n | % | OR (95%CI)a |
P-value | OR (95%CI)a |
P-value | |
| OGG1 | ||||||||||||||||
| Ser/Ser | 17 | 25.4 | 39 | 32.2 | 1.00 | 1.00 | 8 | 25.8 | 39 | 32.3 | 1.00 | 1.00 | ||||
| Ser/Cys | 33 | 49.2 | 54 | 44.6 | 1.40 (0.69–2.87) |
0.355 | 1.34 (0.64–2.81) |
0.439 | 16 | 51.6 | 54 | 44.6 | 1.44 (0.56–3.71) |
0.445 | 1.23 (0.44–3.43) |
0.695 |
| Cys/Cys | 17 | 25.4 | 28 | 23.1 | 1.39 (0.61–3.19) |
0.434 | 1.31 (0.56–3.08) |
0.530 | 7 | 22.6 | 28 | 23.1 | 1.22 (0.40–3.75) |
0.730 | 1.54 (0.45–5.23) |
0.491 |
| MUTYH | ||||||||||||||||
| Gln/Gln | 13 | 19.4 | 37 | 30.6 | 1.00 | 1.00 | 6 | 19.4 | 37 | 30.6 | 1.00 | 1.00 | ||||
| Gln/His | 38 | 56.7 | 69 | 57.0 | 1.57 (0.74–3.30) |
0.237 | 1.55 (0.72–3.32) |
0.263 | 15 | 48.4 | 69 | 57.0 | 1.34 (0.48–3.75) |
0.576 | 1.00 (0.33–3.01) |
0.999 |
| His/His | 16 | 23.9 | 15 | 12.4 | 3.04 (1.18–7.82) |
0.021 | 2.50 (0.95–6.62) |
0.065 | 10 | 32.3 | 15 | 12.4 | 4.11 (1.27–13.33) |
0.019 | 3.20 (0.89–11.49) |
0.075 |
a: OR adjusted for gender, age, smoking habit