Table 4.
Pharmacokinetic analysis- Population estimates for the therapeutic dose of I131 KAb201.
| Parameter | Intra-arterial group | Intravenous group | |
|---|---|---|---|
| Volume of distribution | mean (SE) | 0.0032 (0.0004) L | 0.0031 (0.0003) L |
| Elimination rate | mean (SE) | 0.0944 (0.0095) litres/hour | 0.1498 (0.0176) litres/hour |
| Area under Curve | mean (range) | 15801.0 (5673.4, 30011.2) ng/ml | 12411.3 (4748.3, 20713.8) ng/ml |
| Cmax | mean (range) | 1488.7 (644.5, 2328.5) ng/ml | 1812.7 (1002.8, 2600.3) ng/ml |
SE = standard error; L = litre; h = hour; ng = nanogram; ml= millilitres