Table 5.
Pharmacokinetic analysis- Population estimates for radioactivity following administration of the therapeutic dose of I131 KAb201.
| Parameter | Intra-arterial group | Intravenous group | |
|---|---|---|---|
| Volume of distribution | mean(SE) | 0.0600 (0.0048) L | 0.0611 (0.0024) L |
| Elimination rate | mean(SE) | 0.1461 (0.0179) litres/hour1 | 0.1992 (0.0224) litres/hour |
| Area under Curve | mean (range) | 5509.0 (3245.3, 11049.7) ng/ml | 4854.9 (3482.6, 6272.5) ng/ml |
| Cmax | mean (range) | 806.0 (608.8, 1191.4) ng/ml | 982.2 (754.4, 1386.9) ng/ml |
SE = standard error; L = litre; h = hour; ng = nanogram; ml= millilitres.