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. 2009 Mar 16;106(14):5813–5818. doi: 10.1073/pnas.0810550106

Fig. 1.

Fig. 1.

miR-375-null mice develop diabetes. (A) Random-fed blood glucose levels in 375KO (filled squares) and wild-type littermate control (open circles) male mice. (B and C) Plasma insulin and glucagon levels in 10-week-old 375KO mice (black bars) and wild-type (gray bars) male mice. (D) Intraperitoneal glucose tolerance test administered to 10-week-old mice. (E) Plasma insulin levels during i.p. glucose tolerance test. (F) Insulin secretion of isolated islets in response to indicated glucose concentrations. (G) Insulin tolerance test of 375KO and wild-type littermates (n = 5).