Table 3. Haplotype associations and Renal Cancer Risk.
| Gene/Haplotypes | Cases (%) | Controls (%) | OR1 | 95% CI | Unadjusted p-value | Adjusted p-value1 |
| CASP1/5/4/12 haplotype | ||||||
| Region 1 (chr11: 104429456-104390522) | ||||||
| G-G-G-T-T-A-C-G-T | 41.8 | 45.0 | 1.00 | |||
| G-G-G-T-C-A-C-A-C | 28.1 | 26.7 | 1.14 | 0.97–1.34 | 0.12 | |
| G-G-G-C-T-C-A-G-C | 10.6 | 8.1 | 1.40 | 1.10–1.78 | 0.007 | |
| A-G-G-T-T-A-C-G-T | 5.5 | 7.4 | 0.80 | 0.60–1.07 | 0.13 | |
| Global p-value | 0.14 | 0.16 | ||||
| EGFR haplotype | ||||||
| Region 1 (chr7 55122130-55123913) | ||||||
| C-G-T | 36.8 | 36.0 | 1.00 | |||
| C-A-A | 21.8 | 24.7 | 0.87 | 0.73–1.03 | 0.09 | |
| T-G-T | 20.1 | 21.2 | 0.93 | 0.78–1.12 | 0.20 | |
| C-G-A | 21.4 | 18.1 | 1.13 | 0.94–1.36 | 0.40 | |
| Global p-value | 0.04 | 0.06 | ||||
| Region 2 (chr 7 55129830-55138684) | ||||||
| C-G-G | 29.5 | 29.9 | 1.00 | |||
| T-A-G | 25.0 | 25.9 | 0.99 | 0.82–1.18 | 0.88 | |
| T-G-G | 16.7 | 17.3 | 1.00 | 0.79–1.26 | 0.98 | |
| C-A-G | 11.3 | 12.1 | 0.94 | 0.72–1.24 | 0.67 | |
| T-G-A | 11.1 | 8.5 | 1.32 | 1.02–1.70 | 0.03 | |
| C-G-A | 6.4 | 6.4 | 1.07 | 0.76–1.52 | 0.70 | |
| Global p-value | 0.31 | 0.30 | ||||
| Region 3 (chr 7 55143370-55147338) | ||||||
| A-T-G | 34.4 | 38.4 | 1.00 | |||
| A-G-G | 22.6 | 22.7 | 1.11 | 0.91–1.34 | 0.30 | |
| G-G-G | 20.8 | 18.7 | 1.26 | 1.04–1.53 | 0.02 | |
| A-T-A | 12.3 | 11.8 | 1.14 | 0.90–1.43 | 0.28 | |
| G-T-G | 9.7 | 7.0 | 1.55 | 1.14–2.11 | 0.005 | |
| Global p-value | 0.007 | 0.006 | ||||
| IGFBP3 haplotype | ||||||
| Region 1 (chr 7 45940583-45921554) | ||||||
| T-A-A-T-T-C-A-G | 38.5 | 38.1 | 1.00 | |||
| T-A-A-G-C-C-A-A | 19.8 | 21.5 | 0.94 | 0.78–1.13 | 0.52 | |
| T-A-A-T-C-C-A-G | 15.3 | 17.9 | 0.87 | 0.71–1.05 | 0.15 | |
| T-A-G-T-C-G-A-A | 19.6 | 16.9 | 1.17 | 0.98–1.41 | 0.08 | |
| T-G-A-T-T-C-A-G | 3.6 | 3.3 | 1.07 | 0.73–1.58 | 0.73 | |
| A-A-G-T-C-G-A-A | 1.3 | 1.0 | 1.13 | 0.60–2.11 | 0.70 | |
| Global p-value | 0.19 | 0.21 | ||||
| Region 2 (chr 7 45918779-45916095) | ||||||
| T-G-C | 48.6 | 51.3 | 1.00 | |||
| A-G-C | 18.6 | 15.2 | 1.27 | 1.06–1.54 | 0.01 | |
| T-G-T | 13.8 | 15.4 | 0.93 | 0.75–1.16 | 0.54 | |
| T-A-C | 14.3 | 14.5 | 1.02 | 0.82–1.27 | 0.83 | |
| T-A-T | 4.7 | 3.1 | 1.62 | 1.05–2.51 | 0.03 | |
| Global p-value | 0.03 | 0.04 | ||||
| VCAM1 haplotype | ||||||
| Region 1 (chr 1: 100961998-100966793) | ||||||
| C-A-C | 45.3 | 45.9 | 1.00 | |||
| C-C-C | 18.8 | 17.4 | 1.10 | 0.89–1.35 | 0.40 | |
| C-A-T | 20.3 | 16.5 | 1.25 | 1.01–1.54 | 0.04 | |
| T-A-C | 8.3 | 10.6 | 0.81 | 0.63–1.04 | 0.09 | |
| C-C-T | 6.1 | 8.6 | 0.75 | 0.55–1.02 | 0.07 | |
| Global p-value | 0.02 | 0.03 | ||||
SNPs included within haplotype regions:
CASP1/5/4/12: region 1: rs1785883, rs508760, rs7934239, rs501626, rs11821722, rs568910, rs492859, rs3181318, rs507879.
EGFR: region 1: rs759169, rs11238349, rs12535226; region 2: rs11977660, rs6593205, rs6954351; region 3: rs7796139, rs759158, rs7796872.
IGFBP3: region 1: rs10235181, rs13232606, rs2453836, rs903889, rs924140, rs2471551, rs9282734, rs3110697; region 2: rs6670, rs13223993, rs2270628.
VCAM1 chr1: region 1: rs3917009, rs3917010, rs3176867.
1
Adjusted for age, sex, and center.