Table 5. Results from Replication of SNP rs507879 and Renal Cancer Risk.
| SNP/Genotypes | CEERC1 | US Kidney (Whites only)1 | Combined (Whites only)1 | Combined (All)2 , 3 | ||||||||||||
| Cases | Controls | OR | 95% CI | Cases | Controls | OR | 95% CI | Cases | Controls | OR1 | 95% CI | Cases | Controls | OR1 | 95% CI | |
| CASP 1/5/4/12 | ||||||||||||||||
| rs507879 (T90A) | ||||||||||||||||
| TT | 212 | 337 | 1.00 | 208 | 190 | 1.00 | 420 | 527 | 1.00 | 458 | 590 | 1.00 | ||||
| CT | 381 | 481 | 1.29 | 1.03–1.60 | 334 | 276 | 1.10 | 0.85–1.42 | 715 | 757 | 1.20 | 1.01–1.41 | 840 | 944 | 1.19 | 1.02–1.39 |
| CC | 179 | 209 | 1.39 | 1.07–1.82 | 154 | 127 | 1.10 | 0.80–1.49 | 333 | 336 | 1.25 | 1.02–1.53 | 440 | 472 | 1.28 | 1.07–1.54 |
| CT+CC | 1.31 | 1.07–1.61 | 1.10 | 0.87–1.39 | 1.22 | 1.04–1.42 | 1.22 | 1.05–1.41 | ||||||||
| p-trend | 0.01 | 0.53 | 0.02 | 0.007 | ||||||||||||
1
Adjusted for age, sex and study center.
2
Association among African-Americans in US Kidney Cancer Study (n = 270 cases and 384 controls, CT: OR: 1.23 (0.77–1.97); CC: OR: 1.37 (0.85–2.23); p-trend = 0.21.
3
Adjusted for age, sex, center and race.