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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Dec 6;1790(3):161–172. doi: 10.1016/j.bbagen.2008.11.008

Fig. 4.

Fig. 4

Effects of non-conservative mutation of the WT 360AspValGlu362 (DVE) motif on cleavage by ADAMTS-4 (p68). The significance of the DVE sequence in the IGD was examined by producing the mutant D360L to generate LVE, the sequence preceding the more susceptible sites in the CS-2 domain. The WT (DVE) was also mutated to 360AspGlnLys362 (V361Q-E362K) and 360HisGlnLys362 (D360H-V361Q-E362K).