Table 1.
Demographic and clinical characterization of the study samples.
| Control (n=19) | MDD (n=18) | |
|---|---|---|
| Proportion Female (n) | 58% (11) | 61% (11) |
| Age (mean±SD) | 31 ± 8.5 | 31 ± 11 |
| Proportion Right-Handed (n) | 100% (19) | 100% (18) |
| Depression Ratings | ||
| MADRS (mean±SD) | 0.47 ± 1.2 | 22 ± 5.3 |
| IDS-C (mean±SD) | 0.59 ± 1.3 | 27 ± 6.5 |
| Anxiety Ratings | ||
| HAMA (mean±SD) | 0.59 ± 1.2 | 12 ± 4.3 |
| Anhedonia IDS_C Ratings (Mean ± SD) | 0.06 ± 0.2 | 9.4 ± 3.2 |
| Psychomotor Speed – Response latency on RVIP | 437±78 | 491±118 |
| Age-at-Illness-Onset (yrs) mean±SD (range) | N/A | 19 ± 10 (6 – 41) |
| Illness Duration (years) mean±SD (range) | N/A | 12 ± 8.5 (2 – 32) |
| Duration Medication-Free, Mos. mean±SD (range) | N/A | 23 ± 35 (4 – 96) |
| Treatment Naïve (n) | 19 | 11 |
| Subjects with Remote History of Suicide Attempts (n) | 0 | 4 |
| Prior Exposure to Antipsychotic Agent (n) | 0 | 1 |
| Remote History of Alcohol (2) or Marijuana (1) Abuse (n) | 0 | 3 |
| Comorbid Anxiety Disorder (n) | 0 | 5 |
Abbreviations. MADRS, Montgomery Asberg Depression Rating Scale; HAM-A, Hamilton Rating Scale for Anxiety; IDS-C, Inventory of Depressive Symptoms-Clinician Rated; RVIP, Rapid Visual Information Processing