Table 2.

The mean and standard deviation of regional [C-11]NNC-112 binding potential values. The a priori hypothesis was tested in the striatal regions-of-interest (caudate, putamen). Analyses of D₁-receptor binding in extrastriatal tissues were performed post-hoc.

Region		Healthy Control		Major Depressive Disorder		Group Difference
		Mean	SD	Mean	SD	t	p
VP	right	2.41	0.47	2.34	0.42	0.48	0.64
	left	2.57	0.51	2.40	0.40	1.15	0.26
DP	right	2.49	0.45	2.50	0.33	−0.11	0.92
	left	2.66	0.42	2.57	0.34	0.72	0.48
MC	right	2.66	0.53	2.59	0.41	0.47	0.64
	left	2.07	0.46	1.78	0.30	2.21	0.03*
DC	right	2.77	0.58	2.73	0.39	0.28	0.78
	left	2.40	0.45	2.19	0.46	1.39	0.17
AVS	right	2.19	0.47	2.09	0.37	0.73	0.47
	left	1.86	0.42	1.67	0.35	1.65	0.11
Amygdala	right	1.64	0.55	1.52	0.43	0.79	0.44
	left	1.63	0.76	1.47	0.43	0.88	0.39
Insula	right	0.70	0.13	0.69	0.14	−0.42	0.68
	left	0.69	0.12	0.68	0.16	−1.40	0.17
ACC	bilateral	1.02	0.23	1.03	0.23	−0.45	0.66

Abbreviations: ACC-anterior cingulate cortex; AVS-anteroventral striatum; DC-dorsal caudate; DP-dorsal putamen; MC-middle caudate; VP-ventral putamen