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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Eur J Pain. 2008 Jun 24;13(4):380–386. doi: 10.1016/j.ejpain.2008.05.008

Fig. 1.

Fig. 1

QHEND reduces mechanical allodynia in the CFA model of inflammatory pain in naïve rats. Inflammatory injury was induced by injection of CFA and mechanical allodynia tested using von Frey filaments. Inoculation of QHEND (open circles) but not QOZHG (filled squares) 3 days prior to CFA significantly reduced mechanical allodynia (a); P < 0.01, general linear model, repeated measures test (SPSS); n = 6 animals per group. The antiallodynic effect of QHEND was reversed by intrathecal (10 μg) (b) or intraperitoneal (10 mg/kg) (c) naloxone-methiodide (Nal-M) tested 3 days after CFA; behavioral testing was carried out 30 min after administration of Nal-M; **P < 0.01 pre Nal-M (filled bars) vs post Nal-M (open bars), t-test; n = 6 animals per group.