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Dose-response curves for the effect of the 3-hydroxy-derivatives on intracellular Ca2+ in HEK-293 cells overexpressing the human recombinant TRPV1 receptor. Data are expressed as percent of the effect of 4 μM ionomycin (maximal response). Data are means of at least N = 3 experiments. Standard errors are not shown for the sake of clarity and were never higher than 10% of the means. HETE, hydroxyeicosatetraenoic acid; HAEA, hydroxy-anandamide.
