TABLE 4.

Multiple regression models for variables associated with changes in lathosterol, campesterol, and cholestanol levels during statin treatment

	Standardized Beta Coefficient	P value
Δ Lathosterol modela
Age, y	−0.099	0.034
Gender, m/f	0.001	0.977
Treatment, rosuvastatin / atorvastatin	−0.013	0.766
Baseline lathosterol, μmol/L	−0.838	<0.001
Baseline total cholesterol, mg/dl	0.128	0.030
Changes in total cholesterol, mg/dl	0.315	<0.001
Δ Campesterol modelb
Age, y	0.093	0.215
Gender, m/f	0.142	0.067
Treatment, rosuvastatin / atorvastatin	0.236	0.001
Baseline campesterol, μmol/L	−0.543	<0.001
Baseline total cholesterol, mg/dl	0.011	0.908
Changes in total cholesterol, mg/dl	0.264	0.004
Δ Cholestanol modelc
Age, y	0.008	0.925
Gender, m/f	0.191	0.022
Treatment, rosuvastatin / atorvastatin	0.173	0.026
Baseline cholestanol, μmol/L	−0.561	<0.001
Baseline total cholesterol, mg/dl	0.065	0.513
Changes in total cholesterol, mg/dl	0.150	0.121

In the linear regression models, changes in total lathosterol, campesterol, and cholestanol (in mg/dl) respectively served as outcome variables, while age, gender, statin treatment, baseline total cholesterol, total cholesterol changes, and depending on the model, baseline lathosterol, campesterol, and cholestanol served as independent variables.

^aAdjusted R squared = 0.781.

^bAdjusted R squared = 0.417.

^cAdjusted R squared = 0.321.