Fig. 2.

Aberrant recapitulation of developmental epigenetic landmarks in multiple sclerosis. This drawing illustrates the major epigenetic events occurring in differentiating oligodendroglial cells during development (green) and leading to repression of the differentiation inhibitors Hes5 and stathmin. In the brain of multiple sclerosis patients, in contrast, these repressive epigenetic events are replaced by activating events (red arrow) leading to re-expression of differentiation inhibitors (Hes5) and of molecules destabilizing the cytoskeletal network of oligodendroglial cells (stathmin).