Fig. 8.

Café-au-lait spots found in MAS. a This girl demonstrates typical skin lesions on the face with jagged “coast-of-Maine” borders. Note that skin lesions are bilateral, but that the lesion on the neck tends to respect the midline. b The lateral view of the same patient seen in a demonstrates how the lesions can sometimes tend to follow the developmental lines of Blashko. Also of note is the obvious goiter in this girl with hyperthyroidism. c Skin lesions can often be subtle. These lesions demonstrate coast-of-Maine borders and respect the midline. Again, note that there are lesions on both the right and left. The location of the lesion on the buttocks is a typical location and appearance for a skin lesion seen in association with FD. This girl had FD and skin spots, but no endocrine dysfunction