Figure 1.
Impaired proliferation and vascular network formation in endothelial cells from Per2m/m mice. A, Vascular network formation is decreased in Per2m/m lung endothelial cells. Representative images of 9 separate experiments. B, Quantitative assessment of vascular network formation (tube length) (n=9). C, Migration of lung endothelial cells in wound healing assay is maintained (n=4). D, Adhesion of lung endothelial cells is maintained in Per2m/m cells (n=4). E, Cell proliferation is decreased in Per2m/m lung endothelial cells in crystal violet assay (n=11). *P<0.05 vs WT.