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Chemical structure of allosteric modulators of Class B GPCR’s. A. CRF1 receptor antagonists (SSR125543A [27]; antalarmin [89]; DMP904 [23]; NBI 30775 [8]; NBI 35965 [29]). For a review of CRF1 receptor antagonist chemical structure see ref [43]. B. Glucagon receptor antagonist [6, 13]. C. CGRP antagonist [75]. D. GLP-1 receptor antagonist [86]. E. GLP-1 receptor agonist [44].
