Table I.
Results of fertilization and embryo development in vivo (using IUCS) and in vitro (Group 1)
| 7 patients |
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|---|---|---|---|---|
| 81 COC1 |
||||
| 79 MII2 oocytes |
||||
| 74 successfully injected MII oocytes |
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|
in vitro culture |
in vivo culture |
|||
| Day 0 | ||||
| Allocated injected oocytes | 40 | 34 | ||
| Day 1* | ||||
| 2PN | 30/40 | 75.0% | 23/34 | 67.6% |
| 1PN | 0/40 | 0.0% | 2/34 | 5.9% |
| ≥3PN | 7/40 | 17.5% | 4/34 | 11.8% |
| Zero PN | 3/40 | 7.5% | 3/34 | 8.8% |
| Not retrieved | 2/34 | 5.9% | ||
| Day 3** | ||||
| Q13 | 5/30 | 16.7% | 8/23 | 34.8% |
| Q24 | 9/30 | 30.0% | 7/23 | 30.4% |
| Q35 | 10/30 | 33.3% | 4/23 | 17.4% |
| Q46 | 6/30 | 20.0% | 4/23 | 17.4% |
| Day 5*** | ||||
| Q1 | 4/30 | 13.3% | 4/23 | 17.4% |
| Q2 | 6/30 | 20.0% | 6/23 | 26.1% |
| Q3 | 5/30 | 16.7% | 4/23 | 17.4% |
| Q4 | 15/30 | 50.0% | 9/23 | 39.1% |
| Embryos for ET | 3 | 4 | ||
| Embryos frozen | 9 | 8 | ||
1Cumulus–oocyte complexes, PN: pronuclei, ET: embryo transfer.
2Metaphase II.
3Q1: excellent quality.
4Q2: good quality.
5Q3: fair quality.
6Q4: poor quality.
Using Fisher’s exact probability test:
*P = 0.29, for fertilization in the in vitro versus in vivo culture arms.
**P = 0.41, for distribution of embryo quality on Day 3 in in vitro versus in vivo culture arms.
***P = 0.86, for distribution of embryo quality in in vitro versus in vivo culture arms.