Fig. 4.

Identification of distant structure analogs using vector search. A: The experimental model structure of the first domain (T0187_1) of a putative glycerate kinase from T. maritima found B a structural analog cobalt precorrin-4methyltransferase CbiF domain 2 (1cbf) using a vector search program. C: The first model prediction of one group (Brooks, Group 373) is based on this parent template. D: Another CASP5 target domain (T0149_2) was linked to T0187_1 by using a different definition of core secondary structural elements (includes the purple strand). The vector search program identified (E) homoserine dehydrogenase domain 2 (1ebf_B149-337) and (F) heat shock protein HSP90 (1a4h_A1-214) as distant structural analogs of target T0149_2. Secondary structural elements belonging to the core fold are colored according to type: β-sheets are yellow and α-helices are blue. The β-strand colored in purple represents a core element in target T0149_2 and related structures. The β-strand colored green is deleted in target T0149_2 and related structures. Secondary structural elements that are treated as insertions are colored white.