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. Author manuscript; available in PMC: 2009 Mar 17.
Published in final edited form as: J Biol Chem. 2005 Nov 18;281(7):4173–4182. doi: 10.1074/jbc.M510628200

FIGURE 2. Structural alignment of the primary amino acid sequence of HIV-1, SIV, and ASV INs.

FIGURE 2

Residues shaded in yellow, gray, and green in HIV-1 IN are proposed from the structural model presented in Fig. 1 to be in close proximity to base pairs 1– 4, 5–15, and 16 –20, respectively, of the LTR DNA ends. The HIV-1 LTR end sequence is: 5′-TGTGGAAAATCTCTAGCAGT-3′. Blue-shaded residues in ASV IN mark those unique to all three INs. A dash indicates no amino acid in the corresponding structures. Bold letters above the HIV-1 sequence indicate residues that change in drug-resistant IN mutants (60 – 64). The alignment was compiled by Snasel et al. (73).