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. Author manuscript; available in PMC: 2009 Mar 17.
Published in final edited form as: Mol Ther. 2005 Oct;12(4):618–633. doi: 10.1016/j.ymthe.2005.05.006

FIG. 6. Bilateral long-term striatal expression of rAAV5-siHUNT-1 delays the clasping phenotype of R6/1 mice.

FIG. 6

(A and B) Animal weight was recorded weekly starting at 1 week postsurgery (Fig. 2B). (A) The mean (±SEM) weight for wild-type littermate controls is shown. There was no effect of rAAV-siHUNT-1 treatment on weight regardless of genetic background or vector treatment, including rAAV5-GFP (rAAV repeated-measures ANOVA, F[2,22] = 0.63, P > 0.5). (B) The mean (±SEM) weight for R6/1 mice is shown. In general, R6/1 mice weighed less than age-matched littermate controls (n = 5) over the period of the experiment (F[1,22] = 4.7, P = 0.04 A vs B). (C) There was a significant difference in rotarod performance (mean latency to fall (s) +SEM) between R6/1 and wild-type mice but no difference among groups of R6/1 or wild-type mice treated with rAAV5-GFP or rAAV5-siHUNT-1 or untreated controls (*P = 0.0005). (D) Tail-suspension tests were performed weekly beginning at 6 weeks postsurgery (corresponding to 13 weeks of age) on age-matched control R6/1 mice (n = 5) and R6/1 mice injected bilaterally with rAAV5-siHUNT-1 (n = 5) or rAAV5-GFP (n = 5). Data are presented as percentage of animals scoring positive on the test as a function of time.