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. 2008 Dec 10;101(2):665–671. doi: 10.1152/jn.90806.2008

FIG. 6.

FIG. 6.

Bath application of quinpirole reduced the frequency but not the amplitude of mIPSCs. mIPSCs with amplitudes exceeding 10 pA were recorded from GPe neurons with ACSF containing NBQX (10 μM), CPP (30 μM), and TTX (1 μM). A: sample traces of mIPSCs. B and C: frequencies and amplitudes of mIPSCs before and during application of 5–20 μM quinpirole. Quinpirole significantly diminished the frequencies but not the mean amplitudes of mIPSCs. The pretreatment of slices with 10 μM methysergide, a serotonin receptor antagonist, did not occlude 20 μM quinpirole effects on the frequency of mIPSCs (B). Paired t-test compared with control (*P < 0.05, **P < 0.01). D: cumulative amplitude distributions of mIPSCs recorded from a GPe neuron show no amplitude shift with 20 μM quinpirole (P > 0.05, Kolmogorov-Smirnov test).