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. 2008 Nov 26;101(2):672–687. doi: 10.1152/jn.90953.2008

FIG. 3.

FIG. 3.

Enhanced augmentation in dmGluRA modified in dfmr1;dmGluRA mutants. A: representative traces of EJC responses during a prolonged (1 min) 10-Hz stimulation train in the genetic background control (top), dmfr1 null (2nd), dmGluRA null (3rd), and dmfr1;dmGluRA double null (bottom). Arrows denote initiation of the high-frequency stimulation (HFS) train. Both dmGluRA and dfmr1;dmGluRA show a dramatic increase in augmentation during prolonged HFS. Scale bars 20 nA, 2 s. B: normalized EJC amplitudes during the 10-Hz stimulation train as a function of time (s) since HFS initiation. Quantification shows the 1st 30 s of 10-Hz HFS. C: mean EJC amplitudes for each genotype during 1 min of basal stimulation (0.5 Hz) and during HFS (10 Hz). Sample sizes: control (n = 7), dfmr1 (n = 9), dmGluRA (n = 8), and dfmr1;dmGluRA (n = 10). Significance indicated as P < 0.001 (***).

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