FIG. 4.
Hyperpotentiation in dmGluRA reduced in dfmr1;dmGluRA double mutant. A: representative traces of EJC responses during the PTP period after an HFS train (1 min at 10 Hz). The black bar denotes the end of HFS train. A hyper-elevated potentiation is manifest in the dmGluRA null, which is not present in control, the dfmr1 null or the dfmr1;dmGluRA double mutant. Scale bar: 10 nA, 2 s. B: quantification of normalized EJC amplitudes after the 10-Hz HFS train, highlighting PTP during the first 30 s of post-HFS 0.5-Hz stimulation. Sample sizes: control (n = 6), dfmr1 (n = 9), dmGluRA (n = 10), and dfmr1;dmGluRA (n = 10). C: quantification of the hyperpotentiation phenotypes defined as >5-fold increase from basal EJC amplitude (Ai). The dmGluRA null animals show significantly longer-lasting potentiation compared with all other genotypes. Significance indicated as P < 0.001 (***).