FIG. 10.

Responses to cues, example of cell showing a state effect. Activity of an LC neuron around cue onset in the valid cue condition of the reward schedule task. Responses are stronger in 1st trials but, in addition, the activation is significantly stronger for the cue indicating the 1 trial schedule (which is both 1st and rewarded). The response to the cue indicating the 2nd trial of 3 trials schedules, which is neither 1st nor rewarded, is the weakest. The 6-level state factor accounts for significantly more variance than either 1st or reward factors. This cell was classified as displaying a state effect.