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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Microbes Infect. 2008 Apr 22;10(7):773–780. doi: 10.1016/j.micinf.2008.04.008

Fig. 2.

Fig. 2

Early host defense against ΔmglA involves MyD88 and IFN-γ but is independent of T or B cells. 24 CFU/lung ΔmglA were deposited by aerosol in the lungs of wild type, MyD88-/-, IFN-γ-/-, and Rag2-/- C57BL/6 mice. Mice were euthanized at 7 and 14 days post-infection. The left lung, median lobe of liver, and spleen were removed, homogenized, and quantitatively cultured. Spleens of wild type mice were not cultured on day 14. Bars indicate mean values. The data shown are from one of two similar experiments with comparable deposition doses. A third experiment depositing 102 CFU/lung ΔmglA in wild type and Rag2-/- mice each treated with rabbit polyclonal Ig confirmed the enhanced clearance phenotype at 7 and 14 days in Rag2-/- mice. * indicates p<0.05, ** p<0.01, and *** p<0.001 between groups by ANOVA and Tukey’s post-test.