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Amino-acid Bayesian tree of Smads focusing on worm and fly proteins. The four canonical fly Smads: Mad, dSmad2, dSmad4, and Dad (in black) define the three functional classes of Smads: receptor Smads, Co-Smads and inhibitory Smads. Worm Smads are shown in pale green. Branch lengths are shown in red. Node probabilities are shown in black. The tree is rooted using the N. vectensis I-Smad: EDO39628 (in red).
