Table 3.

Association between CPA4 variants and advanced prostate cancer, stratified by age at diagnosis (using 66 years as cutpoint)

		Age < 66 years				Age ≥ 66 years
SNP	Genotype	Cases	Controls	Odds Ratio (95% CI)*	p-value	Controls	Cases	Odds Ratio (95% CI)*	p-value
rs901799	CC	178 (74.8)	173 (72.7)	1		199 (74.3)	185 (69.0)	1
	CA	56 (23.5)	61 (25.6)	0.89 (0.59–1.36)	0.60	60 (22.4)	75 (28.0)	1.35 (0.91–2.00)	0.14
	AA	4 (1.7)	4 (1.7)	0.98 (0.24–4.00)	0.98	9 (3.4)	8 (3.2)	0.96 (0.36–2.54)	0.93
rs3807344	AA	109 (45.8)	90 (37.8)	1		111 (41.4)	104 (38.8)	1
	AG	98 (41.2)	120 (50.4)	0.67 (0.46–0.99)	0.05	124 (46.3)	123 (45.9)	1.06 (0.73–1.53)	0.76
	GG	31 (13.0)	28 (11.8)	0.91 (0.51–1.64)	0.76	33 (12.3)	41 (15.3)	1.33 (0.78–2.26)	0.30
rs1569132	AA	85 (35.7)	82 (34.5)	1		83 (31.0)	87 (32.5)	1
	AG	98 (41.2)	121 (50.8)	0.78 (0.52–1.17)	0.23	131 (48.9)	136 (50.8)	0.99 (0.67–1.46)	0.96
	GG	55 (23.1)	35 (14.7)	1.51 (0.90–2.55)	0.12	54 (20.2)	45 (16.8)	0.80 (0.48–1.31)	0.37
rs1038628	GG	106 (44.5)	107 (45.0)	1		105 (39.2)	103 (38.4)	1
	GT	91 (38.2)	102 (42.9)	0.91 (0.61–1.35)	0.62	119 (44.4)	129 (48.1)	1.11 (0.76–1.61)	0.60
	TT	41 (17.2)	29 (12.2)	1.44 (0.82–2.53)	0.20	44 (16.4)	36 (13.4)	0.83 (0.49–1.41)	0.50
rs2171492	GG	107 (45.0)	108 (45.4)	1		104 (38.8)	109 (40.7)	1
	GT	90 (37.8)	107 (45.0)	0.86 (0.58–1.27)	0.44	126 (47.0)	126 (47.0)	0.95 (0.66–1.38)	0.79
	TT	41 (17.2)	23 (9.7)	1.83 (1.02–3.36)	0.04	38 (14.2)	33 (12.3)	0.83 (0.48–1.42)	0.49
rs1488009	AA	186 (78.2)	190 (79.8)	1		197 (73.5)	216 (80.6)	1
	AG	49 (20.6)	46 (19.3)	1.09 (0.69–1.72)	0.71	68 (25.4)	44 (16.4)	0.58 (0.38–0.90)	0.01
	GG	3 (1.3)	2 (0.8)	1.53 (0.25–9.31)	0.65	3 (1.1)	8 (3.0)	2.47 (0.64–9.46)	0.19

* From unconditional logistic regression model adjusted for age, ethnicity, and medical institution.