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. 2009 Feb 17;64A(4):426–434. doi: 10.1093/gerona/gln057

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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

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Figure 6. — Change of the relative methylation status of subtelomere with aging. The H-M area/HpaII area of >9.4 kb portion and the M-H area/MspI area of the 4.4 kb>, portion are used as indices indicating the subtelomeric methylation of longer and shorter (than 4.4 kb) telomeres, respectively. (A, Whole population; B, Men; C, Women). In participants in their 60s, the longer (>9.4 kb) telomeres contain more methylated subtelomeres and the shorter telomere (<4.4 kb) contains less methylated subtelomeres. This pattern is opposite to the pattern of the MspI columns >9.4 and <4.4 kb in the participants in their 60s in Figure 1. Horizontal bars depict the standard errors.