Table 1.

AORs Obtained From Multiple Logistic Regression Models of Two Threshold Definitions of Clinically Relevant Increases in CES-D-12 Depressive Symptoms (ie, ≥0.5 SD [Panel A] and ≥1.0 SD [Panel B]) at 1-Year (n = 2,014) and 5-Year (n = 1,516) Postbaseline

Risk Factor	1 y AOR	1 y AOR Adjusted for Baseline CES-D-12 Scores	1 y AOR Adjusted for Baseline CES-D-12, MMSE, and Eight SF-36 Scale Scores	5 y AOR	5 y AOR Adjusted for Baseline CES-D-12 Scores	5 y AOR Adjusted for Baseline CES-D-12, MMSE, and Eight SF-36 Scale Scores
Panel A: Using the ≥0.5 SD threshold definition for clinically relevant increases
Treatment group
Memory	0.809	0.798	.827	0.782	0.776	.774
Reasoning	0.857	0.881	.875	1.034	1.074	1.056
Speed-of-processing	0.700 (p = .012)	0.703 (p = .013)	.697 (p = .013)	0.698 (p = .023)	0.703 (p = .027)	.693 (p = .027)
Panel B: Using the ≥1.0 SD threshold definition for clinically relevant increases
Treatment group
Memory	0.711	0.707	.736	0.772	0.770	.771
Reasoning	0.874	0.889	.884	1.131	1.157	1.126
Speed-of-processing	0.669 (p = .039)	0.672 (p = .042)	.667 (p = .041)	0.651 (p = .059)	0.656 (p = .064)	.668 (p = .083)

Note: AORs = adjusted odds ratios; CES-D-12 = Center for Epidemiological Studies–Depression scale, 12-Item Version; MMSE = Mini-Mental State Examination; SF-36 = Short Form 36-Item Health-Related Quality of Life (and includes the physical functioning [10 items], role limitations due to physical functioning [four items], bodily pain [two items], general health perceptions [five items], vitality [four items], social functioning [two items], role limitations due to emotional problems [three items], and mental health [five items] scales).