Table 3.

Multivariable Relationship Between CNS Medication Use and Recurrent Falls^*

CNS Medication Use	Falls (2+ vs 0–1), Crude OR (95% CI)	Exact p Value	Falls (2+ vs 0–1), Adjusted OR (95% CI)	Exact p Value
Use of 2+ agents	2.45 (1.71–3.51)	<.0001	1.95 (1.35–2.81)	.0004
Use of 1 agent	1.79 (1.41–2.27)	<.0001	1.55 (1.22–1.97)	.0004
No use	Reference		Reference
Higher dose use (>3 SDD)	3.47 (2.36–5.09)	<.0001	2.89 (1.96–4.25)	<.0001
Moderate dose use (1–3 SDD)	2.15 (1.58–2.94)	<.0001	1.80 (1.31–2.47)	.0003
Lowest dose use (<1.0 SDD)	1.68 (1.12–2.49)	.01	1.42 (0.95–2.15)	.5971
No use	Reference		Reference
Long-term use	1.48 (1.24–1.77)	<.0001	1.76 (1.35–2.28)	<.0001
Short-term use	1.36 (1.11–1.67)	<.001	1.49 (1.11–2.01)	.008
No use	Reference		Reference

Notes CI = confidence interval; CNS = central nervous system; OR = odds ratio; SDD = summated standard daily dose.

^*Multivariable Generalized Estimating Equation analyses adjusted for sociodemographic, health behavior, health status factors, and indications for CNS medications.