Table 1.
Potencies and antagonism of the ataxic and myorelaxant effects of benzodiazepine-type drugs by βCCT in squirrel monkeys
| ED50 mean mg/kg ± SEM)
|
||||
|---|---|---|---|---|
| Drug | Alone | + βCCT (3.0 mg/kg) | Dose Ratioa (mean ± SEM) | P<0.05?b |
| Ataxia | ||||
| lam | 0.07 ± 0.01 | 0.3 ± 0.05 | 4.0 ± 0.50 | Yes |
| Alprazolam | 0.3 ± 0.03 | 0.8 ± 0.08 | 2.7 ± 0.27 | Yes |
| Diazepam | 2.6 ± 0.8 | 8.8 ± 0.5 | 3.6 ± 0.73 | Yes |
| Chlordiazepoxide | 11± 7.1 | >56 | > 3.0 | |
| Zolpidem | 3.0 ± 0.9 | 16 ± 1.2 | 6.0 ± 1.1 | Yes |
| Zaleplon | 3.3 ± 0.3 | 15 ± 1.6 | 4.5 ± 0.8 | Yes |
| Muscle Resistance | ||||
| Triazolam | 0.09 ± 0.01 | 0.1 ± 0.01 | 1.1 ± 0.1 | No |
| Alprazolam | 0.2 ± 0.02 | 0.3 ± 0.00 | 1.5 ± 0.3 | No |
| Diazepam | 1.7 ± 0.2 | 4.4 ± 1.7 | 2.3 ± 0.8 | No |
| Chlordiazepoxide | 27 ± 2.8 | 41 ± 0.00 | 1.5 ± 0.2 | No |
| Zolpidem | 8.8 ± 0.8 | 7.6 ± 0.9 | 0.9 ± 0.2 | No |
| Zaleplon | 9.0 ± 0.7 | 9.2 ± 0.8 | 1.0 ± 0.4 | No |
ED50 is the dose of drug resulting in 50% of the maximum effect.
a
Dose ratio = agonist + βCCT ED50 divided by agonist alone ED50.
b
Difference between agonist and agonist + βCCT, Student’s t-tests.