Figure 7. Involvement of the ryanodine receptor in sustentacular cell calcium signaling.
(A–B) Representative traces from 2 sustentacular (A) and 2 OSNs (B) during acute superfusion of caffeine (10–50 mM). (▲indicates time of UTP, caffeine, or odorant superfusion). Right panels: Average peak amplitudes are shown *, p<0.01. (C) Representative trace from a sustentacular cell superfused with UTP in the absence and presence of tetracaine (500 μM). (▲indicates time of UTP superfusion, □ indicates time of drug superfusion). Right panel: Average normalized peak amplitudes are shown as is the predicted peak amplitude for the second application. *, p<0.001. (D–E) Two representative traces from sustentacular cells repetitively superfused with UTP in the presence (D) or absence (E) of ryanodine (50 μM). (▲indicates time of UTP superfusion, □ indicates time of drug superfusion). Right panels: Average normalized peak amplitudes are shown.*, p<0.001.