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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Cancer Gene Ther. 2008 Nov 14;16(4):362–372. doi: 10.1038/cgt.2008.80

Figure 4.

Figure 4

Viral biodistribution following i.c. injection of CRAd-S-pk7 and AdWT was investigated in the blood, lung and liver by determination of viral genomic copies using qPCR for viral gene E1A. (a) Comparison of the number of viral genomic copies of AdWT (gray line) and CRAd-S-pk7 (black line) in the blood (left), lung (middle) and liver (right) of Syrian hamsters showed no difference between these two vectors (P>0.05). (b) Comparison of the number of viral genomic copies of AdWT (gray line) and CRAd-S-pk7 (black line) in the blood (left), lung (middle) and liver (right) of cotton rats showed a significantly lower number of genomic copies of CRAd-S-pk7 in comparison with AdWT in blood (days 1 and 7 following i.c. injection) and in the lung (day 1 following i.c. injection) (P<0.05). For graphic representation on a logarithmic scale, 0 was substituted for 1.