Table 2.
Scaffolds delivering protein for tissue regeneration
| Material | Proteins | Applications | Reference |
|---|---|---|---|
| Natural: | |||
| Collagen | FGF-2 | Tissue development and remodeling, cellular proliferation, angiogenesis | 139,161 |
| PDGF-BB | Blood vessel maturation | 139 | |
| VEGF | Angiogenesis | 139 | |
| HB-EGF | Wound healing | 139 | |
| TGF-β | Chondrogenesis | 110 | |
| Fibrin | NGF | Promote neurite extension and axonal guidance in CNS and PNS injuries | 77,101 |
| bFGF | Angiogenesis; wound healing | 79,109 | |
| Synthetic: | |||
| PLGA | BMP-4/VEGF | Osteoinduction and angiogenesis | 86 |
| NGF | Neural regeneration | 64,73,76,131,132,162–165 | |
| VEGF | Angiogenesis | 166,167 | |
| EVAc | bFGF | Neural regeneration; angiogenesis | 145,168 |
| PEG | TGF-β | Smooth muscle matrix deposition | 169 |
| Hybrid: | |||
| PLGA/Fibrin | FGF-1 | Promote wound healing while inducing angiogenesis | 140 |
| PCL/TCP/Fibrin | BMP-2 | Bone regeneration | 170 |
| HAC-PLA | BMP | Osteogenesis, osteoinduction | 171 |
| PLGA/PEG/PPF | Osteogenic peptide TP508 | Osteogenesis | 172 |