Table 1.
Subject demographics
| Controls | HD | Stage I | Stage II | Stage III and IV | |
|---|---|---|---|---|---|
| Demographics | N = 22 | N = 33 | N = 8 | N = 14 | N = 9 |
| Age | 42.1 ± 8.2 (30–57) | 45.3 ± 8.4 (30–57) | 48.7 ± 5.9 (42–57) | 42.4 ± 9.0 (30–55) | 44.3 ± 7.7 (33–57) |
| Gender | 13F, 9M | 19F, 14M | 4F, 4M | 9F, 5M | 4F, 5M |
| Education (years)a | 16.7 (12–21) | 14.4 (11–18) | 15.7 (11.5–18) | 13.2 (11–18) | 14.8 (12–18) |
| CAG Repeat Lengthb | N/A | 45.4 (41–56) | 43.4 (42–47) | 46.6 (43–56) | 46.7 (45–50) |
| TFCc | N/A | 8.5 ± 3.0 | 11.5 ± 0.8 | 9.1 ± 1.0 | 4.3 ± 1.7 |
| UHDRS Cognitive Scores† | |||||
| Verbal Fluency | 43.4 ± 11.5 | 22.0 ± 12.9 | 40.3 ± 7.7 | 19.0 ± 7.3 | 12.3 ± 8.5 |
| Symbol Digit | 58.7 ± 9.7 | 24.9 ± 12.1 | 37.5 ± 11.5 | 23.5 ± 6.9 | 13.1 ± 7.0 |
| Stroop Color Word | 44.5 ± 7.8 | 26.4 ± 11.2 | 40.4 ± 11.7 | 24.5 ± 7.3 | 18.3 ± 5.0 |
Data presented as mean ± SD, where appropriate. UHDRS = Unified Huntington’s Disease Rating Scale; TFC = total functional capacity; N/A= not available.
a
Education available for N = 26 HD, N = 22 controls.
b
CAG available for N = 30 HD.
c
UHDRS cognitive scores available for 29 HD subjects, N = 21 controls.