. 2009 Apr 3;5(4):e1000362. doi: 10.1371/journal.ppat.1000362

Table 2. Effect of the FPR antagonist cyclosporine H (CsH) on Mycobacterium butyricum-(Myco. but.) induced Met-enkephalin release from human and rat neutrophils and on nociceptive thresholds in complete Freund's adjuvans induced hindpaw inflammation.

Opioid peptide release
Met-enkephalin [fmol/10⁷ neutrophils]	Control	Myco. but.	CsH 10 µM Myco. but.	CsH 100 µM Myco. but.
Human neutrophils	39.3±4.2	143.8±12.1^*	66.7±8.3^* ^§	n.d.
Rat neutrophils	18.5±2.2	239.3±11.9^*	n.d.	148.6±7.3^* ^§

*: p<0.05 (one way repeated measures ANOVA, Student-Newman-Keuls method) vs. Control medium.

§: p<0.05 versus Myco. but. (0.66 mg/ml) (human: n = 16–18; rat: n = 7–14; n.d. = not determined).

¶: p<0.05 versus 0 min (one way repeated measures ANOVA, Duncan's method, n = 10–16).