Table 2.
Temporal changes in serum inorganic phosphate (Pi) and alkaline phosphatase (AP): mean ± SD (n)
| Phenotype | 1 month | 3 months | 9 months | ||||
|---|---|---|---|---|---|---|---|
| Pi (mg/dl) | AP (U/L) | Pi (mg/dl) | AP (U/L) | Pi (mg/dl) | AP (U/L) | PIC | |
| Male | |||||||
| WT | 8.6 ± 1.2 (5) | 1180 ± 206 | 9.3 ± 1.2 (5) | 610 ± 140 | 9.4 ± 1.1 (5) | 506 ± 43 | 0.399 ± 0.20 (4) |
| WT + TG | 8.3 ± 1.0 (4) | 1217 ± 260 | 7.8 ± 0.94 (3) | 502.0 ± 46.0 | 8.2 ± 1.7 (4) | 454 ± 40 | 0.46 ± 0.12 (4) |
| HYP | 5.3 ± 0.7*(8) | 2484 ± 504* | 5.6 ± 1.3*(6) | 1196 ± 275* | 5.6 ± 1.7*(8) | 993 ± 217 | 0.65 ± 0.37 (5) |
| HYP + TG | 5.7 ± 0.6*(5) | 1911 ± 708 | 5.4 ± 1.4*(3) | 733 ± 190 | 6.7 ± 1.2 (5) | 686 ± 60** | 0.78 ± 0.84 (3) |
| Female | |||||||
| WT | 9.0 ± 0.9 (3) | 1915 ± 147 | 7.8 ± 1.5 (3) | 708 ± 125 | 6.1 ± 0.5 (3) | 639 ± 110 | 0.029 ± 0.010 (3) |
| WT + TG | 8.5 ± 1.1 (5) | 1765 ± 494 | 8.2 ± 0.9 (2) | 699 ± 187 | 7.4 ± 1.4 (5) | 647 ± 98 | 0.248 ± 0.19 (3) |
| HYP | 5.3 ± 0.7*(17) | 2357 ± 522 | 5.4 ± 1.1*(11) | 1023 ± 250 | 4.9 ± 4 (17) | 910 ± 235 | 0.67 ± 0.55 (11) |
| HYP + TG | 6.6 ± 0.4*(3) | 2558 ± 336 | 4.7 (1) | 780 | 6.1 ± 1.5 (3) | 724 ± 90 | 0.64 ± 0.88 (2) |
Note:PIC phosphate clearance, WT wild type, TG transgene, HYP hypophosphatemia. Samples in which there was obvious hemolysis are not included in these data.
*
Significantly different from WT of the same gender.
**
Significantly different from same genotype with the TG