Figure 1.

Initial and total changes in expression of 566 intracellular signaling cascade-associated genes in rat liver regeneration. The solid line denotes the up-regulated genes; the dashed line represents the down-regulated genes. A. The initial expression patterns. B. The total expression patterns. Δ = intracellular receptor-mediated signaling pathway; ▪ = second messenger-mediated signaling pathway; • = nitric oxide-mediated signaling pathway; + = hormone-mediated signaling pathway; ▪ = carbohydrate-mediated signaling pathway; ▴ = protein kinase cascade; × = small GTPase-mediated signal transduction; * = ER-nuclear signaling pathway; □ = target of rampamycin (TOR) signaling pathway.