Table 1.

Examples of catalytic antioxidants with H₂O₂-scavenging activity that are effective in attenuating oxidative stress in in vivo models..

Model system	Species	Active site	Compound(s)	Reference
Pulmonary
Bleomycin fibrosis	Mice	Mn	AEOL 10201	[57]
Radiation fibrosis	Rats	Mn	AEOL 10113	[59]
		Mn	AEOL 10150	[60]
		Mn	EUK 189	[61]
Cigarette smoke	Rats	Se	DPDS	[54]
		Mn	AEOL 10150	[55]
Endotoxin	Pigs	Mn	EUK 8	[66]
Bronchopulmonary dysplasia	Preterm baboons	Mn	AEOL 10113	[64]
Antigen-induced asthma	Mice	Mn	AEOL 10113	[50]
Hemorrhage	SOD3 KO mice	Mn	AEOL 10150	[65]
Cardiovascular
Heart ischemia/reperfusion	Mice	Se	BXT 51072	[68]
	Aged rats	Mn	EUK 8	[110]
	Rats	Mn	AEOL 10113	[69]
Dilated cardiomyopathy	SOD2 KO mice	Mn	AEOL 10201	[111]
	Harlequin mutant mice	Mn	EUK 8	[83]
Sepsis	Rats	Mn	AEOL 10113	[84]
		Mn	EUK 8	[81]
Hemorrhage	Rats	Mn	EUK 8	[67]
		Mn	EUK 134
Nervous system
Neurofibromatosis	Flies	Mn	AEOL 10201	[112]
		Mn	AEOL 10150
MPTP	Monkeys	Se	Ebselen	[97]
	Mice	Mn	AEOL 11207	[22]
ALS	Mutant SOD1	Mn	AEOL 10150	[105]
	Tg mice	Mn	EUK 8	[106]
		Mn	EUK 134
Stroke	Rats	Se	Ebselen	[74]
		Mn	EUK 134	[73]
	Mice	Mn	AEOL 10113	[72]
		Mn	AEOL 10150
	Humans	Se	Ebselen	[75]
Spinal cord trauma	Rats	Mn	AEOL 10201	[113]
		Se	Ebselen	[114]
	Mice	Mn	AEOL 10150	[115]
Cerebral vasoconstriction	Amyloid Tg mice	Mn	AEOL 10201	[108]
	Rats	Mn	AEOL 10201	[109]
Cognitive function	Aged mice	Mn	EUK 189	[103]
		Mn	EUK 207
Hepatic/gastrointestinal/renal
Ischemia/reperfusion	Rat	Mn	AEOL 10150	[70]
		Mn	EUK 134	[76]
		Se	Ebselen	[71]
Endotoxin	Mice	Se	Ebselen	[85]
		Mn	AEOL 10113	[82]
	Rats	Mn	EUK 134	[86]
Fas	Mice	Mn	AEOL 10201	[116]
Ethanol	Rats	Se	Ebselen	[117]
Carbon tetrachloride	Rats	Se	Ebselen	[118]
Hyperthermia	Aged rats	Mn	EUK 189	[119]
Colitis	Rats	Mn	AEOL 11201	[120]