Fig. 4.

The inherent regenerative capacity of motor neurons after crush injury is not influenced by Schwann cell-expressed mutant SOD1. The speed of nerve regeneration (measured by the toe spread) after unilateral crush injury was assessed at 2 time points [at 4 months (A), presymptomatic, and at 8.5 months (B), onset] before the appearance of overall symptoms (at 11.5 months). No significant differences were detected between LoxSOD1^G37R/P₀-cre and LoxSOD1^G37R ALS mice (n = 5 mice per group; only males used), indicating that removal of mutant SOD1^G37R from Schwann cells did not influence the sciatic nerve's inherent regenerative capacity (similar results were obtained with females; Fig. S4A).